Monoclonal or polyclonal… or neither?

A vast array of research methods utilise the immunological power of antibodies to identify antigens of interest. That is, in a lab, if you want to track a particular molecule in a sample you want to study, one of the best things you can do is apply an antibody known to recognise your target and see whether it sticks. Successful “sticking” can be visualised and quantified by labelling the antibody with a fluorescent dye, either by direct fusion or by application of a fluorescently labelled secondary antibody. While this seems simple enough, we rely heavily on assumptions about the specificity of the antibody for target molecule, and it is here that our decision to use either monoclonal or pol

ERS/BALR pulmonary epithelium seminar

The Berlin wall: A metaphor for epithelial wall function? Thanks to the BALR travel award, I (and 4 other award winners) was lucky enough to attend the ERS and the BALR held a joint seminar on 'New developments in in vitro models of the pulmonary epithelium'. The seminar was organised by Colin Bingle and Terry Tetley and spread over 3 days, starting Thursday afternoon and continuing to Saturday morning, and held in the German capital of Berlin. Airway epithelial cells play many important roles in the body: forming the alveoli and allowing gas exchange, barrier function, carrying out mucocilliary clearance and acting as part of the immune system. Therefore, it is important that we develop and

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Charity number: SC010151