Research Fellow at the University of Southampton
Section: Allergy, Immunity and Respiratory
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Location: Southampton General Hospital
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Salary: £35,880 per annum - Full Time Fixed Term until 31/08/2029
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Closing Date: Sunday 02 March 2025
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Interview Date: To be confirmed
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Reference: 3002625FC
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An exciting opportunity to join a national research programme with the aim of speeding up the diagnosis and treatment of rare respiratory diseases.
The LifeArc Centre for Rare Respiratory Diseases is co-led by Southampton. The PCD Group at UOS is recruiting a Research Fellow to develop scalable advanced cell models for primary ciliary dyskinesia (PCD), including CRISPR-Cas 9 editing of a ciliated airway cell line. Characterisation of the models will confirm genetic, molecular and cellular defects relating to cilia motility, prior to high throughput testing of novel therapies. Through the national LifeArc collaboration you will have opportunities to network and work with scientists and clinicians from other institutions working on various aspects of the programme; also opportunities to integrate with industrial partners and patient advocacy groups.
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Research Associate in Bioinformatics at the University of Cardiff
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Location: Division of Biomedicine, School of Biosciences, Cardiff University
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Salary: £40,247 - £45,163 per annum (Grade 6). Appointments to roles at Cardiff University are usually made at bottom of scale unless in exceptional circumstances.
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Closing date: Friday, 7 March 2025
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Reference: 19595BR
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We are seeking to appoint a highly motivated and passionate computational biologist / postdoctoral fellow to join our team as part of the UKRI-funded Future Leader Fellowship project investigating epigenetic regulation of lung fibrosis led by Dr Renata Jurkowska at the School of Biosciences, Cardiff University.
You will work closely with a PhD student and an experimental/wet-lab postdoc and play a key role in advancing our research efforts, with a primary focus on data mining and integration to address complex bioinformatics and biomedical problems in the context of chronic lung diseases. Specifically, you will develop computational approaches for data analysis and integrate various omics data from healthy and diseased lungs across disease stages to identify changes associated with disease development and progression.
The ideal candidate may hold a PhD degree in biology, bioinformatics, computer science, or a related field, and possess strong programming skills. Rich experience in bioinformatics, including but not limited to NGS data analysis, epigenomics, multi-omics, and integration of complex datasets. Nevertheless, we are open to different types of profiles, including those from the industry.
This position is full-time (35 hours per week) and fixed term until 31st May 2028.
Secondment opportunity welcome - please note for Cardiff University members of staff interested in this post on a secondment basis, permission will need to be sought from your current Line Manager before applying.
Please contact Renata Jurkowska (JurkowskaR@cardiff.ac.uk) for an informal, confidential discussion about the role.
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Research Associate/Fellow (Fixed term) - University of Nottingham
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Area: School of Medicine, Translational Medical Sciences
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Location: University Park
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Salary: £31,387 to £46,485 per annum (pro rata if applicable) depending on skills and experience (minimum £34866 with relevant PhD). Salary progression beyond this scale is subject to performance.
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Closing Date: Tuesday 25 February 2025
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Interview Date: To be confirmed
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Reference: MED417724X1
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Previous applicants in the last 6 months need not apply
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Applications are invited for a Research Associate/Fellow to work on a Medical Research Council funded project using multiple molecular genetics techniques including high throughput CRISPRi screens, lung cell and tissue models in the laboratory of Professors Ian Sayers and Gleb Yakubov (Biodiscovery Institute, University of Nottingham, UK).
In this highly collaborative project involving the Universities of Nottingham, Leicester, Manchester, Imperial College London and AstraZeneca we aim to advance our understanding of the genetic, molecular and cellular basis of mucus production in the airways of patients with severe asthma. This includes using a multidisciplinary approach to translate these findings to new mechanistic understanding and therapeutic opportunities.
In Nottingham, we will use human primary airway cells combined with CRISPRi to identify functional causal genetic variants, genes and pathways important for regulation of mucins and characterise the mucus produced and functional effects on cells. These mechanisms will be explored further using samples collected from patients with asthma.
This position will be especially suited to candidates with interest in functional genomics, bioinformatics, lung cell biology and respiratory medicine. The successful candidate will also work in close collaboration with researchers in Leicester, Manchester, Imperial College London and AstraZeneca and additional collaborators. This post offers a unique opportunity to work in fast developing field of molecular genetics and to develop skills in state-of-the-art technologies.
Applicants must be highly motivated and self-driven, with a PhD or equivalent (or near to completion of PhD), in genomics, molecular and cell biology or related area of biological science. The successful candidate will ideally have considerable experience in some of the following areas: handling and analysing large genomic datasets, CRISPR/Cas9 genome editing and other molecular biology approaches. A track record of publishing research and experience in primary human airway cell culture is also desirable.
This is a full time (36.25 hours) fixed-term contract offered for 3 years. Applications are also welcome from candidates wishing to work part-time (minimum 29 hours per week). Please specify in your application if you wish to work part time and the number of preferred hours. Job share arrangements may be considered.
Requests for secondment from internal candidates may be considered on the basis that prior agreement has been sought from both your current line manager and the manager of your substantive post, if you are already undertaking a secondment role.
For more information on our lab activities please visit: https://www.nottingham.ac.uk/medicine/people/ian.sayers
Informal enquiries may be addressed to Ian Sayers, email: Ian.Sayers@nottingham.ac.uk. Please note that applications sent directly to this email address will not be accepted.
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Further details:
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